Yini i-familia Mediterranean fever (FMF)?

I-Familial Mediterranean Fever yisifo sofuzo se-autosomal esizibonakalisa ngezikhalazo zobuhlungu besisu nomkhuhlane ekuhlaselweni futhi singadideka ne-appendicitis eyingozi.

Kuyini Izifo ze-FMF (Imfiva Yomndeni yaseMedithera)?

I-Familial Mediterranean Fever ivame ukubonakala ikakhulukazi emazweni asemngceleni weMedithera. Kuvamile eTurkey, eNyakatho Afrika, ama-Armenia, ama-Arabhu namaJuda. Ngokuvamile yaziwa ngokuthi i-Familial Mediterranean Fever (FMF).

Isifo se-FMF sibonakala ngobuhlungu besisu, ubuhlungu kanye nomuzwa ohlabayo emgodini wezimbambo (i-plevititis) nobuhlungu obuhlangene nokuvuvukala (isifo samathambo) ngenxa yokuvuvukala kolwelwesi lwesisu, oluphindaphindayo ekuhlaselweni futhi lungahlala izinsuku ezingu-3-4. Ngezinye izikhathi, ukubomvu kwesikhumba ngaphambili kwemilenze kungase kwengezwe esithombeni. Ngokuvamile, lezi zikhalazo zingazihambela zodwa phakathi kwezinsuku ezingu-3-4, ngisho noma kungekho ukwelashwa okunikezwayo. Ukuhlasela okuphindaphindiwe kubangela ukuba iphrotheni ebizwa ngokuthi i-amyloid inqwabelane emizimbeni yethu ngokuhamba kwesikhathi. I-Amyloid ivame ukunqwabelana ezinso, lapho ingabangela ukwehluleka kwezinso okungapheli. Ngokwezinga elincane, kungase kuqoqwe ezindongeni zemithambo futhi kubangele i-vasculitis.

Okutholakele emitholampilo kwenzeka ngenxa yokuguquka kwezakhi zofuzo ezibizwa nge-pyrin. Idluliselwa ngofuzo. Nakuba ukuba khona kwezakhi zofuzo ezimbili ezigulayo ndawonye kubangela lesi sifo, ukuthwala isakhi sofuzo akubangeli lesi sifo. Laba bantu babizwa ngokuthi "abathwali".

Yiziphi Izimpawu Zomndeni WaseMedithera Fever (FMF)?

I-Familial Mediterranean Fever (FMF) isifo sofuzo esivamile esifundeni saseMedithera. Izimpawu ze-FMF zingabonakala njengokuquleka kwe-febrile, ubuhlungu obukhulu besisu, ubuhlungu obuhlangene, ubuhlungu besifuba, kanye nesifo sohudo. Ukuquleka kwe-febrile kuqala ngokuzumayo futhi ngokuvamile kuthatha amahora angu-12 kuya kwangu-72, kuyilapho ubuhlungu besisu bunohlamvu olucijile, ikakhulukazi enkabeni. Ubuhlungu obuhlangene buzwakala ikakhulukazi emalungeni amakhulu njengamadolo neqakala, kuyilapho ubuhlungu besifuba bungenzeka ohlangothini lwesobunxele. Isifo sohudo singabonakala ngesikhathi sokuhlaselwa futhi ngokuvamile singazwakala isikhashana.

Sitholakala kanjani isifo se-Family Mediterranean Fever (FMF)?

Ukuxilongwa kwenziwa ngokusekelwe kokutholwe emitholampilo, umlando womndeni, okutholwe ekuhlolweni nasekuhlolweni kwaselabhorethri. Lezi zivivinyo, kanye nokuphakama okuphezulu kwe-leukocyte, ukwanda kwe-sedimentation, ukuphakama kwe-CRP nokuphakama kwe-fibrinogen, kusekela ukuxilongwa kwe-Familial Mediterranean Fever. Inzuzo yokuhlolwa kofuzo ezigulini ilinganiselwe ngoba ukuguqulwa kwezakhi zofuzo okuhlonziwe kuze kube manje kungatholakala kuphela ku-80% weziguli ze-Familial Mediterranean Fever. Kodwa-ke, ukuhlaziywa kwezakhi zofuzo kungase kube usizo ezimweni ze-atypical.

Kungenzeka yini ukwelapha i-Familial Mediterranean Fever Disease (FMF)?

Kunqunywe ukuthi ukwelashwa kwe-colchicine ye-Familial Mediterranean Fever kuvimbela ukuhlaselwa kanye nokuthuthukiswa kwe-amyloidosis engxenyeni enkulu yeziguli. Nokho, i-amyloidosis iseyinkinga engathi sína ezigulini ezingakulandeli ukwelashwa noma ezibambezelekile ekuqaliseni i-colchicine. Ukwelashwa kwe-Colchicine kufanele kube impilo yonke. Kuyaziwa ukuthi ukwelashwa kwe-colchicine kuyindlela yokwelapha ephephile, efanele futhi ebalulekile ezigulini ezinomkhuhlane womndeni waseMedithera. Kunconywa ukusebenzisa noma ngabe isiguli sikhulelwe. I-Colchicine ayizange iboniswe ukuthi inomphumela olimazayo enganeni. Kodwa-ke, kunconywa ukuthi iziguli ezikhulelwe ezinomkhuhlane waseMedithera zomndeni zithole i-amniocentesis futhi zihlole isakhiwo sofuzo sombungu.